The 49ers (2-2) travel to State Farm Stadium for a 1:25 PT kickoff against the Arizona Cardinals (4-0).
Trey Lance gets his first NFL start in place of the injured Garoppolo. Kyler Murray is the Cardinals' QB1. The Cardinals are the NFC's only undefeated team.
The 49ers have won six straight against the Cardinals at State Farm Stadium.[1][2][3]
Trey Lance gets his first NFL start Sunday afternoon at State Farm Stadium. The third-overall pick, ten weeks into his rookie year, gets the kind of road start that the Kyle Shanahan playbook will probably simplify for.
The Cardinals are 4-0 and looking the part of the NFC West favorite. Kyler Murray has thrown for 1,200 yards through four games. DeAndre Hopkins is the WR1 the offense was built around. The 49ers' defense has held all comers, but Kyler is the matchup that has consistently given the 49ers trouble.
The Garoppolo calf injury is not season-ending. Lance is the QB1 for the week. The schedule's first road game post-injury is the kind of test that will tell what Lance is.
Week 5 is the early-NFC West separator. The 49ers (2-2) and Cardinals (4-0) meet with Arizona trying to stay perfect; the Rams are 3-1; the Seahawks are 2-2. Around the conference the Buccaneers and Cowboys are competing for top-tier status. The Sunday game is the kind of week where the loser falls back in the division and the winner stakes a claim.
Through four games the 49ers are 2-2 with a +5 point differential. The Cardinals are 4-0 with a +51. Kyler Murray averages 300 passing yards per game with 9 TDs and 3 INTs. DeAndre Hopkins leads the NFC in receiving yards. Trey Lance makes first NFL start in place of injured Garoppolo. Vegas opens the Cardinals as 5.5-point home favorites; total 51.
| Team | Rec | Strk |
|---|---|---|
| Buffalo Bills | 3-1 | -- |
| Miami Dolphins | 1-3 | -- |
| New England Patriots | 1-3 | -- |
| New York Jets | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Baltimore Ravens | 3-1 | -- |
| Cincinnati Bengals | 3-1 | -- |
| Cleveland Browns | 3-1 | -- |
| Pittsburgh Steelers | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Tennessee Titans | 2-2 | -- |
| Houston Texans | 1-3 | -- |
| Indianapolis Colts | 1-3 | -- |
| Jacksonville Jaguars | 0-4 | -- |
| Team | Rec | Strk |
|---|---|---|
| Denver Broncos | 3-1 | -- |
| Las Vegas Raiders | 3-1 | -- |
| Los Angeles Chargers | 3-1 | -- |
| Kansas City Chiefs | 2-2 | -- |
| Team | Rec | Strk |
|---|---|---|
| Arizona Cardinals | 4-0 | -- |
| Los Angeles Rams | 3-1 | -- |
| Seattle Seahawks | 2-2 | -- |
| San Francisco 49ers | 2-2 | -- |
| Team | Rec | Strk |
|---|---|---|
| Dallas Cowboys | 3-1 | -- |
| Washington Football Team | 2-2 | -- |
| New York Giants | 1-3 | -- |
| Philadelphia Eagles | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Green Bay Packers | 3-1 | -- |
| Chicago Bears | 2-2 | -- |
| Minnesota Vikings | 1-3 | -- |
| Detroit Lions | 0-4 | -- |
| Team | Rec | Strk |
|---|---|---|
| Carolina Panthers | 3-1 | -- |
| Tampa Bay Buccaneers | 3-1 | -- |
| New Orleans Saints | 2-2 | -- |
| Atlanta Falcons | 1-3 | -- |
49ers @ Cardinals Week 5 2021
NFL 2021 Season Week 5 San Francisco 49ers @ Arizona Cardinals
Week 5 San Francisco 49ers Vs. Arizona Cardinals Commentary 10/10/2021
49ers vs. Cardinals Week 5 Highlights | NFL 2021
49ers vs. Cardinals Week 5 Highlights | NFL 2021 (RelPicks)
San Francisco 49ers vs Arizona Cardinals Highlights 2nd QTR | Week 5 | NFL Season 2021-22
San Francisco 49ers vs Arizona Cardinals Highlights 1st QTR | Week 5 | NFL Season 2021-22
49ers vs. Cardinals Week 5 Highlights | NFL 2021
N@teD@wg Presents... ...49ers @ Cards | Week 5 | 2021 NFL Season HighlightsReveal each quarter as you watch, the next quarter stays hidden until you tap it.
| Team | Play | Score |
|---|---|---|
| Cardinals | James Conner 1 yard rush ( Matt Prater kick) | 0-7 |
| Team | Play | Score |
|---|---|---|
| Cardinals | Matt Prater 21 yard field goal | 0-10 |
| Team | Play | Score |
|---|---|---|
| 49ers | Deebo Samuel 13 yard rush ( Joey Slye kick) | 7-10 |
| Team | Play | Score |
|---|---|---|
| Cardinals | DeAndre Hopkins 9 yard pass from Kyler Murray ( Matt Prater kick) | 7-17 |
| 49ers | Joey Slye 47 yard field goal | 10-17 |
The Arizona Cardinals beat the 49ers 17-10 at State Farm Stadium, improving to 5-0 for the first time since 1974. Kyler Murray completed 22-of-31 for 239. DeAndre Hopkins caught a 9-yard touchdown with 5:13 remaining. Trey Lance, in his first NFL start, finished 15-of-29 for 192 yards and one interception plus 89 rushing yards on 16 carries. The 49ers' defense stopped Lance on four-of-five fourth-down conversion attempts. The 49ers fell to 2-3.[1][2][3]
Trey Lance made his first NFL start Sunday afternoon and the 49ers lost 17-10 at State Farm Stadium. The Cardinals improved to 5-0 for the first time since 1974.
Lance threw for 192 yards on 29 attempts with one INT, ran for 89 yards on 16 carries, and led the team in rushing. The 49ers were 1-of-5 on fourth down. DeAndre Hopkins caught the 9-yard touchdown that put Arizona ahead with 5:13 left.
The Cardinals' defense, stopping a rookie quarterback on four straight fourth-down attempts, was the day's story. Lance looked like a rookie. The kind of first start that will produce more questions than answers in the postgame Monday film session. 2-3. The bye comes up next.
Cardinals 17, 49ers 10. Margin: -7. Five-game record: 2-3, -2 differential.
A 17-10 loss in Arizona. The 49ers fall to 2-3.
How it unfolded
The 49ers scored first on a field goal. The Cardinals answered with a Murray touchdown drive. The teams traded field goals in the second quarter. Murray's touchdown made it 10-3 by the half. Lance led the 49ers on a long drive that ended in a touchdown to make it 10-10. Hopkins caught his 9-yard touchdown with 5:13 left to give Arizona the 17-10 lead. The 49ers' last possession ended on a fourth-down failure.
The turning point
The DeAndre Hopkins touchdown. With the game tied at 10 in the fourth quarter, Murray's throw to Hopkins despite tight coverage from Josh Norman was the deciding play.
By the numbers
Lance 15-of-29 for 192 with one INT plus 89 rushing yards. Murray 239 passing on 31 attempts. Hopkins 87 receiving on 6 catches with the late TD. The 49ers ran for 174 as a team (with Lance leading).
Personnel watch
Lance in his first NFL start. The fourth-down struggles defined the afternoon. The 49ers' defense kept Arizona to 17 but could not get the late stop when it mattered.
What it means
2-3 with the bye next week. The Garoppolo-vs-Lance starter question will be the lead storyline for the entire two-week stretch. The Colts come up after the bye in a Sunday-night spot.
| Player | C/A | Yds | TD | Int | Rate |
|---|---|---|---|---|---|
| SFO | |||||
| Trey Lance | 15/29 | 192 | 0 | 1 | |
| ARI | |||||
| Kyler Murray | 22/31 | 239 | 1 | 0 | |
| Player | Att | Yds | TD | Long |
|---|---|---|---|---|
| SFO | ||||
| Trey Lance | 16 | 89 | 0 | 15 |
| Elijah Mitchell | 9 | 43 | 0 | 14 |
| Deebo Samuel | 1 | 13 | 1 | 13 |
| Trey Sermon | 1 | 7 | 0 | 7 |
| Kyle Juszczyk | 1 | 0 | 0 | 0 |
| ARI | ||||
| Rondale Moore | 3 | 38 | 0 | 26 |
| James Conner | 10 | 29 | 1 | 8 |
| Chase Edmonds | 6 | 15 | 0 | 5 |
| Christian Kirk | 1 | 11 | 0 | 11 |
| Kyler Murray | 7 | 1 | 0 | 10 |
| Player | Rec | Yds | TD | Long |
|---|---|---|---|---|
| SFO | ||||
| Deebo Samuel | 3 | 58 | 0 | 26 |
| Kyle Juszczyk | 3 | 35 | 0 | 18 |
| Brandon Aiyuk | 2 | 32 | 0 | 26 |
| Ross Dwelley | 2 | 25 | 0 | 13 |
| Elijah Mitchell | 2 | 19 | 0 | 14 |
| Mohamed Sanu | 2 | 19 | 0 | 13 |
| Charlie Woerner | 1 | 4 | 0 | 4 |
| ARI | ||||
| DeAndre Hopkins | 6 | 87 | 1 | 30 |
| Rondale Moore | 5 | 59 | 0 | 33 |
| Christian Kirk | 5 | 39 | 0 | 9 |
| Chase Edmonds | 3 | 19 | 0 | 10 |
| Maxx Williams | 1 | 14 | 0 | 14 |
| A.J. Green | 1 | 13 | 0 | 13 |
| James Conner | 1 | 8 | 0 | 8 |
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Find the thread Start the threadCanonical title: [Rewatch Party] 2021 W5 - 49ers at Arizona Cardinals - Game Thread