The 49ers (2-2) travel to Bank of America Stadium for a 1:00 ET kickoff against the Carolina Panthers (1-3).
Baker Mayfield starts at quarterback for Carolina. Christian McCaffrey is still the Panthers' RB1. The 49ers come off the Monday night home win over the Rams.
Baker Mayfield is in his first year as the Panthers' starter, the kind of year that gets a quarterback discussed in terms of his last team. Christian McCaffrey is still the Panthers' RB1, which is the kind of trade-deadline storyline that hovers over every Sunday for a 1-3 team.
The 49ers are favored by 7 in Carolina. Garoppolo has now started three weeks and the offense is finally looking like it has more than one dimension.
The matchup favors the 49ers. McCaffrey may not play. Sunday is the kind of road game where a contender takes care of business.
Week 5 is the early-October NFC playoff-picture preview. The 49ers (2-2) need a road win to move above .500 for the first time. Around the conference the Eagles remain undefeated; the Vikings and Cowboys are 3-1. The NFC South is in the kind of mess that the Panthers' Sunday is unlikely to fix. The 49ers' Sunday is the kind of week where the favorite has to take care of business and the playoff race continues elsewhere.
Through four games the 49ers are 2-2 with a +25 point differential. The Panthers are 1-3 with a -23. Baker Mayfield averages 195 passing yards per game with 5 TDs and 5 INTs. Christian McCaffrey is questionable (soft tissue). Bosa has 6 sacks through 4 games (league-leading pace). Vegas opens the 49ers as 7-point road favorites; total 41.
| Team | Rec | Strk |
|---|---|---|
| Buffalo Bills | 3-1 | -- |
| Miami Dolphins | 3-1 | -- |
| New York Jets | 2-2 | -- |
| New England Patriots | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Baltimore Ravens | 2-2 | -- |
| Cincinnati Bengals | 2-2 | -- |
| Cleveland Browns | 2-2 | -- |
| Pittsburgh Steelers | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Jacksonville Jaguars | 2-2 | -- |
| Tennessee Titans | 2-2 | -- |
| Indianapolis Colts | 1-2-1 | -- |
| Houston Texans | 0-3-1 | -- |
| Team | Rec | Strk |
|---|---|---|
| Kansas City Chiefs | 3-1 | -- |
| Denver Broncos | 2-2 | -- |
| Los Angeles Chargers | 2-2 | -- |
| Las Vegas Raiders | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Arizona Cardinals | 2-2 | -- |
| Los Angeles Rams | 2-2 | -- |
| Seattle Seahawks | 2-2 | -- |
| San Francisco 49ers | 2-2 | -- |
| Team | Rec | Strk |
|---|---|---|
| Philadelphia Eagles | 4-0 | -- |
| Dallas Cowboys | 3-1 | -- |
| New York Giants | 3-1 | -- |
| Washington Commanders | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Green Bay Packers | 3-1 | -- |
| Minnesota Vikings | 3-1 | -- |
| Chicago Bears | 2-2 | -- |
| Detroit Lions | 1-3 | -- |
| Team | Rec | Strk |
|---|---|---|
| Atlanta Falcons | 2-2 | -- |
| Tampa Bay Buccaneers | 2-2 | -- |
| Carolina Panthers | 1-3 | -- |
| New Orleans Saints | 1-3 | -- |
San Francisco 49ers Top Plays vs. Carolina Panthers | 2022 Regular Season Week 5
San Francisco 49ers vs. Carolina Panthers Week 5 | NFL 2022 Simulation
2022 Week 5: Carolina Panthers (2-2) vs San Francisco 49ers (4-0)
2022 NFL Season - Week 5 - (Predictions) - 49ers at Panthers
49ers Vs Panthers 2022 Pregame video | Week 5
San Francisco 49ers vs. Carolina Panthers | 2022 Week 5 Highlights
49ers vs Panthers Week 5 Highlights | 2022 NFL Season ᴴᴰReveal each quarter as you watch, the next quarter stays hidden until you tap it.
| Team | Play | Score |
|---|---|---|
| 49ers | Tevin Coleman 9 yard pass from Jimmy Garoppolo ( Robbie Gould kick) | 7-0 |
| Team | Play | Score |
|---|---|---|
| 49ers | Robbie Gould 49 yard field goal | 10-0 |
| Panthers | Eddy Piñeiro 43 yard field goal | 10-3 |
| 49ers | Emmanuel Moseley 41 yard interception return ( Robbie Gould kick) | 17-3 |
| Team | Play | Score |
|---|---|---|
| Panthers | Christian McCaffrey 19 yard rush (run failed) | 17-9 |
| 49ers | Deebo Samuel 4 yard pass from Jimmy Garoppolo ( Robbie Gould kick) | 24-9 |
| Panthers | Eddy Piñeiro 37 yard field goal | 24-12 |
| Team | Play | Score |
|---|---|---|
| 49ers | Jeff Wilson 1 yard rush ( Mitch Wishnowsky kick failed) | 30-12 |
| Panthers | Eddy Piñeiro 34 yard field goal | 30-15 |
| 49ers | Tevin Coleman 5 yard rush ( Mitch Wishnowsky kick) | 37-15 |
Jimmy Garoppolo threw for 253 yards and two touchdowns, Emmanuel Moseley intercepted Baker Mayfield and returned it 41 yards for a touchdown, and the 49ers beat the Carolina Panthers 37-15. Jeff Wilson ran for 120 yards and a touchdown. Tevin Coleman scored twice. Mayfield exited late with a foot injury. The Panthers fell to 1-4 under Matt Rhule (11-27 overall). The 49ers improved to 3-2.[1][2][3]
Baker Mayfield is in his first year as the Panthers' starter and Sunday afternoon he left the game with a foot injury. His passer rating before the exit was 60.9. The 49ers won 37-15.
Emmanuel Moseley intercepted Mayfield and returned it 41 yards for a touchdown in the second quarter, the kind of play that announced the 49ers were running away with the afternoon. Jeff Wilson ran for 120. Tevin Coleman scored twice in goal-line situations.
The Panthers, at 1-4 under Matt Rhule and 11-27 in his coaching tenure, look like the team most likely to make a deadline trade and a Black Monday firing announcement. The 49ers, 3-2 now, look like the team that figured out their offense was supposed to be three-dimensional after all.
49ers 37, Panthers 15. Margin: +22. Five-game record: 3-2, +47 differential.
A 37-15 win over the Panthers. The 49ers improve to 3-2.
How it unfolded
The 49ers opened with a Jake Moody field goal. Carolina answered with a field goal of their own. Garoppolo found Aiyuk for a touchdown to make it 10-3. The Panthers blocked a 49ers field goal attempt to spark a brief surge, but on the ensuing possession Moseley intercepted Mayfield and ran it back 41 yards for the pick-6. By the half it was 17-3. The second half was Jeff Wilson and Coleman in short yardage, the 49ers' rushing attack finishing what the passing game opened.
The turning point
Moseley's pick-6. With Carolina trying to capitalize on the blocked field goal and seemingly setting up a one-score game, Moseley intercepted Mayfield's overthrow and turned it into a 17-3 cushion.
By the numbers
Garoppolo 253 passing on 29 attempts with two TDs. Jeff Wilson 120 rushing on 18 carries. Coleman two TDs. Moseley the pick-6. The 49ers outgained Carolina 354 to 209.
Personnel watch
Moseley generated the pick-6 plus a pass break-up. McCaffrey did not play, listed as inactive. The 49ers' offensive line generated the run lanes for Wilson's 120 yards. Bosa added one sack.
What it means
3-2 with the offense finding its rhythm and the defense generating takeaways. The Falcons next week on the road in Atlanta.
| Player | C/A | Yds | TD | Int | Rate |
|---|---|---|---|---|---|
| SFO | |||||
| Jimmy Garoppolo | 18/30 | 253 | 2 | 0 | |
| CAR | |||||
| Baker Mayfield | 20/36 | 215 | 0 | 1 | |
| P.J. Walker | 5/6 | 60 | 0 | 0 | |
| Player | Att | Yds | TD | Long |
|---|---|---|---|---|
| SFO | ||||
| Jeff Wilson | 17 | 120 | 1 | 41 |
| Tevin Coleman | 8 | 23 | 1 | 14 |
| Deebo Samuel | 2 | 12 | 0 | 9 |
| Jimmy Garoppolo | 1 | -1 | 0 | 0 |
| Brock Purdy | 1 | -1 | 0 | -1 |
| CAR | ||||
| Christian McCaffrey | 14 | 54 | 1 | 19 |
| D.J. Moore | 1 | 8 | 0 | 8 |
| D'Onta Foreman | 2 | 2 | 0 | 5 |
| Player | Rec | Yds | TD | Long |
|---|---|---|---|---|
| SFO | ||||
| Brandon Aiyuk | 3 | 58 | 0 | 24 |
| George Kittle | 5 | 47 | 0 | 20 |
| Jauan Jennings | 2 | 45 | 0 | 32 |
| Tevin Coleman | 3 | 44 | 1 | 30 |
| Kyle Juszczyk | 2 | 27 | 0 | 18 |
| Deebo Samuel | 2 | 20 | 1 | 16 |
| Jeff Wilson | 1 | 12 | 0 | 12 |
| CAR | ||||
| Shi Smith | 4 | 69 | 0 | 31 |
| D.J. Moore | 4 | 59 | 0 | 27 |
| Christian McCaffrey | 7 | 50 | 0 | 12 |
| Robbie Chosen | 1 | 32 | 0 | 32 |
| Terrace Marshall Jr. | 4 | 30 | 0 | 12 |
| Giovanni Ricci | 3 | 27 | 0 | 12 |
| Ian Thomas | 2 | 8 | 0 | 6 |
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