2025 season · Week 10

Pregame

AI summary, sourced from 1 period article (ESPN AP)

The 49ers (6-3) host the Los Angeles Rams (6-2) at Levi's Stadium in an NFC West rematch of October's Thursday Night Football game, which San Francisco won 26-23 in overtime.

The 49ers play their seventh straight game without Brock Purdy; Mac Jones makes his ninth start. The Rams enter as 5.5-point favorites. Matthew Stafford has 21 TDs to 2 INTs through eight games, including 16 TDs and no interceptions over his past five.

Davante Adams has five touchdown receptions in his past two games. Both Rams losses came against the Eagles and Lions.[1][2][3]

AI summary, sourced from 1 period article (ESPN AP)

Two games into the season the 49ers' biggest rivalry was the Cardinals. Five weeks later it is the Rams, who have spent the back half of October turning into the team a lot of people expected the 49ers to be.

Matthew Stafford is throwing the ball at an MVP-track pace. Davante Adams is catching everything within eight yards. Puka Nacua remains the NFL receiving leader. The 49ers are mostly Christian McCaffrey and Mac Jones holding things together.

The Eagles and Lions are the two teams that have beaten Los Angeles this year. The 49ers, healthier, would be the third name on that list. Sunday is the kind of Sunday that decides whether they are at all.

AI summary, sourced from 1 period article (ESPN AP)

Week 10 is the first round of the NFC contender face-offs. The 49ers and Rams are tied at the top of the NFC West at 6-3 and 6-2 respectively. The Eagles and Lions remain the conference's top two seeds. The Bears, suddenly, are 8-2 and a wild-card threat that has not been a wild-card threat since the early 2010s. Around the league, the NFC West is the lone three-team playoff race; the NFC South and NFC East have settled into one-team-and-everyone-else. Sunday's Rams visit is the most important regular-season Sunday the 49ers have played in two years. Win it, and the road to the NFC West stays open; lose it, and the wild card is the road back.

AI summary, sourced from 1 period article (ESPN AP)

Through nine games the 49ers are 6-3 with a +6 point differential. The defense, having now lost Bosa and Warner, gives up 21.0 ppg (12th in the league). The run game in Week 9 produced 159 yards. Matthew Stafford has 2,147 passing yards through eight games (21 TDs, 2 INTs) and is on a streak of 16 TDs and no INTs over five games. Davante Adams has seven touchdowns on seven red-zone catches entering Sunday. The first 49ers-Rams game was decided by an Alfred Collins goal-line stop and a Pineiro OT field goal. Vegas opens the Rams as 5.5-point road favorites; the total is 49.5.

League standings entering Week 10

Standings as of kickoff, Week 10 (no future-game spoilers)

Around the league

  • Tied atop the league at 7-2: New England Patriots, Indianapolis Colts, Denver Broncos.

AFC

AFC East

TeamRecStrk
New England Patriots7-2--
Buffalo Bills6-2--
Miami Dolphins2-7--
New York Jets1-7--

AFC North

TeamRecStrk
Pittsburgh Steelers5-3--
Baltimore Ravens3-5--
Cincinnati Bengals3-6--
Cleveland Browns2-6--

AFC South

TeamRecStrk
Indianapolis Colts7-2--
Jacksonville Jaguars5-3--
Houston Texans3-5--
Tennessee Titans1-8--

AFC West

TeamRecStrk
Denver Broncos7-2--
Los Angeles Chargers6-3--
Kansas City Chiefs5-4--
Las Vegas Raiders2-6--

NFC

NFC West

TeamRecStrk
Los Angeles Rams6-2--
Seattle Seahawks6-2--
San Francisco 49ers6-3--
Arizona Cardinals3-5--

NFC East

TeamRecStrk
Philadelphia Eagles6-2--
Dallas Cowboys3-5-1--
Washington Commanders3-6--
New York Giants2-7--

NFC North

TeamRecStrk
Green Bay Packers5-2-1--
Chicago Bears5-3--
Detroit Lions5-3--
Minnesota Vikings4-4--

NFC South

TeamRecStrk
Tampa Bay Buccaneers6-2--
Carolina Panthers5-4--
Atlanta Falcons3-5--
New Orleans Saints1-8--

Game video

▶ Open in YouTube San Francisco 49ers vs.Los Angeles Rams FULL GAME | 2025 NFL Season Week 10 · channel: ScottSauceGaming

If the player above shows only a "Watch on YouTube" tile, the uploader has disabled inline embedding for this video. Click the button to open it on YouTube.

Game info

Roof
outdoors
Surface
grass
Weather
77°F, wind 3 mph
Stadium
Levi's Stadium
Referee
Land Clark
QB matchup
Mac Jones vs Matthew Stafford
Vegas line
49ers -5.5
Over/Under
49.5

Score

Reveal through:

49ers 0, Los Angeles Rams 1449ers 7, Los Angeles Rams 2149ers 14, Los Angeles Rams 2849ers 26, Los Angeles Rams 4249ers 26, Los Angeles Rams 42[1]

1234T
Los Angeles Rams1477141421284242
San Francisco 49ers0771207142626

Scoring plays

Reveal each quarter as you watch, the next quarter stays hidden until you tap it.

Q1

TeamPlayScore
RamsKyren Williams 2 yard rush ( Harrison Mevis kick)7-0
RamsPuka Nacua 22 yard pass from Matthew Stafford ( Harrison Mevis kick)14-0

Q2

TeamPlayScore
RamsDavis Allen 4 yard pass from Matthew Stafford ( Harrison Mevis kick)21-0
49ersJauan Jennings 6 yard pass from Mac Jones ( Eddy Piñeiro kick)21-7

Q3

TeamPlayScore
49ersBrian Robinson Jr. 1 yard rush ( Eddy Piñeiro kick)21-14
RamsDavante Adams 2 yard pass from Matthew Stafford ( Harrison Mevis kick)28-14

Q4

TeamPlayScore
49ersLuke Farrell 9 yard pass from Mac Jones ( Eddy Piñeiro kick failed)28-20
RamsKyren Williams 7 yard rush ( Harrison Mevis kick)35-20
RamsColby Parkinson 16 yard pass from Matthew Stafford ( Harrison Mevis kick)42-20
49ersGeorge Kittle 13 yard pass from Mac Jones (pass failed)42-26

Recap

AI summary, sourced from 1 period article (ESPN AP)

Matthew Stafford threw four touchdown passes with no interceptions, an NFL record-setting third straight game with that line, and the Los Angeles Rams beat the 49ers 42-26 at Levi's Stadium. The Rams scored touchdowns on their first three possessions to take a 21-0 lead early in the second quarter. Stafford completed 24 of 36 for 280 yards; he became the ninth quarterback in NFL history with 400 career touchdown passes. Mac Jones completed 33 of 39 for 319 yards with three touchdowns and one interception for the 49ers. San Francisco falls to 6-4; the Rams improve to 7-2.[1][2][3]

AI summary, sourced from 1 period article (ESPN AP)

Matthew Stafford is having the kind of season where the postscript on a 42-26 win at Levi's Stadium includes him crossing 400 career touchdown passes, throwing four more without an interception in a single afternoon, and giving Sean McVay the rare luxury of a sideline view of an MVP campaign in the middle of November. He did all three Sunday.

The 49ers tried. Mac Jones threw for 319 with three scores. The 49ers offense moved the ball at a 33-for-39 clip when they needed to. The defense, without Bosa and Warner, did not get off the field. The Rams scored touchdowns on their first three possessions and turned a Sunday matchup into a Sunday lesson. 'It is looked like MVP play to me all year, to be honest,' Davante Adams said about his quarterback. He should know.

'We thought we could slow them down and find a way to get them off on third down,' Kyle Shanahan said. They did not slow them down. They did not get them off on third down. 6-4 with the Rams now in front of them in the NFC West and the schedule entering its second half. The wild card is now the road back.

AI summary, sourced from 1 period article (ESPN AP)

Rams 42, 49ers 26. Margin: -16. Ten-game record: 6-4, -10 differential.

  • Stafford: 24-of-36 for 280, 4 TD, 0 INT (NFL-record 3rd straight 4-TD/0-INT game).
  • Stafford career TD passes: now 400+ (9th all-time).
  • Kyren Williams: 2 rushing TDs.
  • Davante Adams: catches in 8 of 9 games this year with a TD.
  • Rams scored TDs on first three possessions.
  • Mac Jones: 33-of-39 for 319, 3 TD, 1 INT.
  • 49ers: 0 sacks of Stafford.
  • 49ers 6-4; Rams 7-2. LAR now alone atop NFC West.
AI summary, sourced from 1 period article (ESPN AP)

A 42-26 loss at Levi's Stadium. The 49ers fall to 6-4.

How it unfolded

Matthew Stafford and the Rams opened on a touchdown drive, then went 80 yards on the second possession for another touchdown, then 75 on the third. The 49ers were down 21-0 before they put points on the board. Mac Jones brought them back into hailing distance with a pair of long touchdown drives in the second and third quarters, but every time the 49ers cut it to a one-score game Stafford answered. Davante Adams caught his eighth touchdown of the season midway through the fourth quarter to put it away. Kyren Williams added two rushing touchdowns. The 49ers' last meaningful possession ended in a fourth-quarter interception.

The turning point

The Rams' opening three possessions. The defense, without Bosa or Warner, gave up touchdowns on three straight long drives to open the game. The 49ers offense could not match that pace. The game was decided by the time Mac Jones found his rhythm.

By the numbers

Stafford 24-of-36 for 280, four TDs, no INTs (NFL record for the third straight game). His career touchdown total crossed 400 in the second half. Mac Jones 33-of-39 for 319, three TDs, one INT; the volume looked good but the time-of-possession battle was lost early. Kyren Williams two rushing TDs. The 49ers' defense did not record a sack.

Personnel watch

The absence of Nick Bosa and Fred Warner showed up Sunday in a way it had not since Week 8. Stafford was not pressured on enough of his dropbacks. The secondary, even with rotational help, could not stay with Adams in the red zone. The offense, returning Pearsall and Jennings, looked fine for a half but was playing from behind the whole afternoon.

What it means

6-4 with the Rams up by a game in the NFC West and a divisional tiebreaker that no longer belongs to San Francisco. The Cardinals on the road next, then Carolina at home in Week 12. The path back to a high seed runs through wild-card math.

Box score

Passing

PlayerC/AYdsTDIntRate
SFO
Mac Jones33/3931931
LAR
Matthew Stafford24/3628040

Rushing

PlayerAttYdsTDLong
SFO
Brian Robinson Jr.841113
Christian McCaffrey123005
Mac Jones1303
LAR
Kyren Williams1473212
Blake Corum1356015
Matthew Stafford3-30-1

Receiving

PlayerRecYdsTDLong
SFO
George Kittle984120
Jauan Jennings671122
Christian McCaffrey866019
Demarcus Robinson334014
Kendrick Bourne119019
Skyy Moore118018
Luke Farrell21519
Kyle Juszczyk2806
Brian Robinson Jr.1404
LAR
Davante Adams677123
Puka Nacua564122
Colby Parkinson441116
Tyler Higbee333015
Terrance Ferguson132032
Xavier Smith114014
Kyren Williams21107
Davis Allen2814

Discuss on Reddit

Find or start the canonical thread for this game on r/49ers. The thread title is deterministic so anyone running this Rewatch lands on the same place.

Find the thread Start the thread

Canonical title: [Rewatch Party] 2025 W10 - 49ers vs Los Angeles Rams - Game Thread